Guy’s & St Thomas’ Foundation has appointed the firm as its development partner on the 5.5-acre scheme, with half of the homes to be affordable.

Work on the residential element is expected to start in spring 2027, subject to final regulatory approvals.

Royal Street already has planning permission for a major mixed-use redevelopment opposite St Thomas’ Hospital, including around 1.2m sq ft of office and laboratory-enabled space alongside homes, shops and public realm.

The six-plot scheme forms a key part of the SC1 London health and life sciences innovation district, which is targeting more than £3bn of investment and up to 6,200 jobs.